The first indication that neem was being used as a medical treatment was about 4,500 years ago. This was the high point of the Indian Harappa culture, one of the great civilizations of the ancient world. In these ancient texts neem is mentioned in almost 100 entries for treating a wide range of diseases and symptoms, most of which continue to vex humanity. Long revered for its many healing properties, neem came close to providing a cradle-to-grave health care program and was a part of almost every aspect of life in many parts of the Indian subcontinent up to and including the modern era.

Origin
Neem is a tropical evergreen native to India and Burma and growen in southeast Asia and western Africa. It can live up to 200 years.

The herb Neem Contains bitters and also quercetin and ß sitosterol glucocide1.